Orlen Unipetrol is a Czech joint stock company owned by a Polish oil company PKN Orlen. The company is engaged in crude oil processing and the production, distribution and sales of fuels and petrochemical products – mainly plastics and fertilisers – in the Czech Republic and the Central European region. It is the only crude oil processing company in the Czech Republic and its earnings rank it among the ten largest Czech companies. It was founded in 1994, and in 2004, it became part of the PKN Orlen group, which owns 100% shares in the company. The following companies have been gradually incorporated into Unipetrol: Kaučuk, Chemopetrol, Benzina, Paramo, Koramo(merged with Paramoin 2003), Česká rafinérská, Unipetrol Trade, Spolana, and Unipetrol Rafinérie.

The Unipetrol group includes refineries and production plants in Litvínov and Kralupy nad Vltavou, Paramo in Pardubice and Kolín with its Mogul brand and Spolana in Neratovice, and two research centres in Litvínov and Brno. The network of Benzina fuel stations – the largest network in the Czech Republic with its 406 stations – is also part of Unipetrol.

Since 2018, the Chairman of the Board has been Krzysztof Zdziarski.