The European School, Brussels I (ESB1) is a European School located in Uccle, Brussels, Belgium.

In keeping with the multilingual and multicultural ethos and curriculum of the European Schools, the four Brussels-based European Schools are divided into language sections, with all schools required to host English, French and German sections. In addition to these, ESB1 comprises Danish, Hungarian, Italian, Polish, and Spanish sections.

Applications for enrolment in the four Brussels-based European Schools are administered centrally, with all applications for those whose mother-tongue is Danish, Hungarian, Polish, Slovenian or Maltese referred automatically to the ESB1, along with applications for enrolment in the nursery and primary cycles of the Latvian section.

Students enrolled in the schools are generally instructed in the language of their respective section. Students must choose from either English, French or German for their second language, which becomes the language of instruction for History and Geography curriculum from the third-year secondary, as well as the optional Economics course available from fourth year. Students are also expected to take a third language upon entering the secondary cycle. Students whose mother-tongue is not covered by a language section, are enrolled in the English, French or German sections, and can opt for their mother-tongue in place of English, French or German studies, respectively.