The Panagia Episkopi is the previous middle-Byzantine cathedral of the Greek Cycladean island of Santorini (Thira).

The church was built in the northern foothills of the Profitis Ilias (Προφήτης Ηλίας), the highest mountain on Santorini. It is approximately 600 metres southeast of the township of Mesa Gonia (Μέσα Γωνιά), which is also referred to as Episkopi Gonias (Επισκοπή Γωνιάς), the name of the previous Episcopal seat. The eastern coast of the island at Kamari (Καμάρι) is approximately two kilometres from the church, and Fira (Φηρά), the capital of the island, is five kilometres to the northwest. Mesa Gonia is connected to the Panagia Episkopi via a partially paved road, which ends in a parking area directly north of the church.